PT  - JOURNAL ARTICLE
AU  - J F Goossens
AU  - N Pommery
AU  - M Lohez
AU  - J Pommery
AU  - N Helbecque
AU  - P Cotelle
AU  - M Lhermitte
AU  - J P Henichart
TI  - Antagonistic effect of a vasoactive intestinal peptide fragment, vasoactive intestinal peptide(1-11), on guinea pig trachea smooth muscle relaxation.
DP  - 1992 Jan 01
TA  - Molecular Pharmacology
PG  - 104--109
VI  - 41
IP  - 1
4099  - http://molpharm.aspetjournals.org/content/41/1/104.short
4100  - http://molpharm.aspetjournals.org/content/41/1/104.full
SO  - Mol Pharmacol1992 Jan 01; 41
AB  - The conformation of various regions of vasoactive intestinal peptide (VIP) has been analyzed by semiempirical methods, CD, and NMR spectroscopy, indicating that residues 11-21 are most likely to be helical, whereas the amino-terminal portion VIP(1-11) could exhibit two beta-turn structures. VIP(1-11) inhibits 125I-VIP binding to intact guinea pig tracheal epithelial cells and the VIP-induced smooth muscle response. However, the endecapeptide exhibits no effect on the muscle tone. All these data suggest that VIP(1-11) may be a useful tool in studying VIP receptor recognition, its regulation, and cellular functions.