PT  - JOURNAL ARTICLE
AU  - Swillens, S
TI  - Dynamic control of inositol 1,4,5-trisphosphate-induced Ca2+ release: a theoretical explanation for the quantal release of Ca2+.
DP  - 1992 Jan 01
TA  - Molecular Pharmacology
PG  - 110--114
VI  - 41
IP  - 1
4099  - http://molpharm.aspetjournals.org/content/41/1/110.short
4100  - http://molpharm.aspetjournals.org/content/41/1/110.full
SO  - Mol Pharmacol1992 Jan 01; 41
AB  - A theoretical model has been elaborated in order to describe the kinetics of Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3). The model is based on the existence of a key molecule that controls the interconversion of open and closed forms of the Ca2+ channel. The model can quantitatively explain the previously obtained experimental observations that showed that a continuous IP3 stimulus leads to a biphasic Ca2+ release and that successive IP3 additions provoke repetitive bursts of Ca2+ release. Other published interpretations of these observations are discussed.