PT  - JOURNAL ARTICLE
AU  - GILLETTE, JAMES R.
AU  - KAMM, JEROME J.
AU  - SASAME, HENRY A.
TI  - Mechanism of <em>p</em>-Nitrobenzoate Reduction in Liver: The Possible Role of Cytochrome P-450 in Liver Microsomes
DP  - 1968 Nov 01
TA  - Molecular Pharmacology
PG  - 541--548
VI  - 4
IP  - 6
4099  - http://molpharm.aspetjournals.org/content/4/6/541.short
4100  - http://molpharm.aspetjournals.org/content/4/6/541.full
SO  - Mol Pharmacol1968 Nov 01; 4
AB  - The following evidence suggests that the reduction of p-nitrobenzoate to p-aminobenzoate by liver microsomes is mediated by cytochrome P-450: (a) carbon monoxide blocks nitroreduction, and the degree of inhibition is proportional to the amount of cytochrome P-450 bound as the carbon monoxide complex; (b) the rate of nitroreduction is proportional to the amount of cytochrome P-450 in liver microsomes from animals previously treated with either phenobarbital or carbon tetrachloride.