TY - JOUR T1 - Mechanism of <em>p</em>-Nitrobenzoate Reduction in Liver: The Possible Role of Cytochrome P-450 in Liver Microsomes JF - Molecular Pharmacology JO - Mol Pharmacol SP - 541 LP - 548 VL - 4 IS - 6 AU - JAMES R. GILLETTE AU - JEROME J. KAMM AU - HENRY A. SASAME Y1 - 1968/11/01 UR - http://molpharm.aspetjournals.org/content/4/6/541.abstract N2 - The following evidence suggests that the reduction of p-nitrobenzoate to p-aminobenzoate by liver microsomes is mediated by cytochrome P-450: (a) carbon monoxide blocks nitroreduction, and the degree of inhibition is proportional to the amount of cytochrome P-450 bound as the carbon monoxide complex; (b) the rate of nitroreduction is proportional to the amount of cytochrome P-450 in liver microsomes from animals previously treated with either phenobarbital or carbon tetrachloride. ER -