RT Journal Article
SR Electronic
T1 Mechanism of <em>p</em>-Nitrobenzoate Reduction in Liver: The Possible Role of Cytochrome P-450 in Liver Microsomes
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 541
OP 548
VO 4
IS 6
A1 GILLETTE, JAMES R.
A1 KAMM, JEROME J.
A1 SASAME, HENRY A.
YR 1968
UL http://molpharm.aspetjournals.org/content/4/6/541.abstract
AB The following evidence suggests that the reduction of p-nitrobenzoate to p-aminobenzoate by liver microsomes is mediated by cytochrome P-450: (a) carbon monoxide blocks nitroreduction, and the degree of inhibition is proportional to the amount of cytochrome P-450 bound as the carbon monoxide complex; (b) the rate of nitroreduction is proportional to the amount of cytochrome P-450 in liver microsomes from animals previously treated with either phenobarbital or carbon tetrachloride.