RT Journal Article
SR Electronic
T1 Increased Synthesis of Catecholamines in the Intact Rat following Administration of α-Adrenergic Blocking Agents
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 457
OP 464
VO 4
IS 5
A1 WALLACE DAIRMAN
A1 ROBERT GORDON
A1 SYDNEY SPECTOR
A1 ALBERT SJOERDSMA
A1 SIDNEY UDENFRIEND
YR 1968
UL http://molpharm.aspetjournals.org/content/4/5/457.abstract
AB The present study was undertaken to evaluate the effects of α-blocking agents on the rate of catecholamine synthesis in vivo. It was found that phentolamine and phenoxybenzamine increase the formation of radioactive norepinephrine and epinephrine in rat tissues when L-tyrosine-14C is used as a precursor but not when L-dopa-3H is the precursor. These findings indicate that α-blocking agents increase catecholamine synthesis by stimulating tyrosine hydroxylase activity.