@article {Matsuoka471, author = {Toshiyuki Matsuoka and Tomoyuki Nishizaki and Kimiaki Sumino}, title = {A Specific Inhibitory Action of Lithium on the 5-HT2cReceptor Expressed in Xenopus laevis Oocytes}, volume = {51}, number = {3}, pages = {471--474}, year = {1997}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The effect of lithium on the phosphoinositide-signaling pathway was examined in 5-HT2C receptors, which are involved in phospholipase C stimulation, expressed in Xenopus laevisoocytes by voltage-clamp recording and assay of intracellular Ca2+ concentrations. Treatment with lithium for 60 sec after the initial application of 5-HT reduced Ca2+-dependent chloride currents in a dose-dependent manner (0.01{\textendash}1 mm) and inhibited intracellular Ca2+release, whereas pretreatment with lithium or injection into oocytes had no effect. Additionally, treatment with lithium for more than 24 hr reduced 5-HT-evoked currents to a much lesser extent. In contrast, the currents through other phosphoinositide-dependent receptors, such as endogenous {\textquotedblleft}serum{\textquotedblright} and muscarinic ACh receptors, were not affected or less affected by a short term or long term treatment with lithium, respectively. These results indicate that lithium may have a specific blocking effect on the 5-HT2C receptors and, in part, nonselectively act on the phosphoinositide metabolic pathway. The American Society for Pharmacology and Experimental Therapeutics}, issn = {0026-895X}, URL = {https://molpharm.aspetjournals.org/content/51/3/471}, eprint = {https://molpharm.aspetjournals.org/content/51/3/471.full.pdf}, journal = {Molecular Pharmacology} }