RT Journal Article
SR Electronic
T1 Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 535
OP 541
DO 10.1124/mol.51.4.535
VO 51
IS 4
A1 Behl, Christian
A1 Skutella, Thomas
A1 Lezoualc’H, Frank
A1 Post, Anke
A1 Widmann, Martina
A1 Newton, Christopher J.
A1 Holsboer, Florian
YR 1997
UL http://molpharm.aspetjournals.org/content/51/4/535.abstract
AB Oxidative stress-induced neuronal cell death has been implicated in different neurological disorders and neurodegenerative diseases; one such ailment is Alzheimer’s disease. Using the Alzheimer’s disease-associated amyloid β protein, glutamate, hydrogen peroxide, and buthionine sulfoximine, we investigated the neuroprotective potential of estrogen against oxidative stress-induced cell death. We show that 17-β-estradiol, its nonestrogenic stereoisomer, 17-α-estradiol, and some estradiol derivatives can prevent intracellular peroxide accumulation and, ultimately, the degeneration of primary neurons, clonal hippocampal cells, and cells in organotypic hippocampal slices. The neuroprotective antioxidant activity of estrogens is dependent on the presence of the hydroxyl group in the C3 position on the A ring of the steroid molecule but is independent of an activation of estrogen receptors.