TY - JOUR T1 - The Specificity of Drug Receptors JF - Molecular Pharmacology JO - Mol Pharmacol SP - 156 LP - 165 VL - 5 IS - 2 AU - H. F. MARLOW AU - J. C. METCALFE AU - A. S. V. BURGEN Y1 - 1969/03/01 UR - http://molpharm.aspetjournals.org/content/5/2/156.abstract N2 - Precipitating antibodies were prepared against the determinant phenoxycholine, a nicotinic agonist. The affinity of the antibody for a wide range of agonists and antagonists related to acetylcholine was tested. The affinity constants were found to range between 3.2 x 105 and 6.9 x 103 M-1. The antibody did not discriminate between agonists and antagonists, or between drugs acting at muscarinic and nicotinic receptors. ER -