PT  - JOURNAL ARTICLE
AU  - ROBERT A. MUELLER
AU  - HANS THOENEN
AU  - JULIUS AXELROD
TI  - Inhibition of Trans-synaptically Increased Tyrosine Hydroxylase Activity by Cycloheximide and Actinomycin D
DP  - 1969 Sep 01
TA  - Molecular Pharmacology
PG  - 463--469
VI  - 5
IP  - 5
4099  - http://molpharm.aspetjournals.org/content/5/5/463.short
4100  - http://molpharm.aspetjournals.org/content/5/5/463.full
SO  - Mol Pharmacol1969 Sep 01; 5
AB  - Reserpine produces a neurally mediated increase in tyrosine hydroxylase activity in the adrenal medullae and sympathetic ganglia of the rat. This increase in enzyme activity can be prevented by the administration of actinomycin D or cycloheximide. These results suggest that the synthesis of tyrosine hydroxylase is regulated either by changes in the release or turnover of catecholamines, or by the direct effect of a neurotransmitter. Reserpine increases the incorporation of 3H-leucine into hepatic and adrenal protein, and this incorporation is inhibited by a dose of cycloheximide that prevents the reserpine-initiated increase in tyrosine hydroxylase activity.