@article {LEVIN499, author = {W. LEVIN and R. KUNTZMAN}, title = {Biphasic Decrease of Radioactive Hemoprotein from Liver Microsomal Carbon Monoxide-Binding Particles}, volume = {5}, number = {5}, pages = {499--506}, year = {1969}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The administration of δ-aminolevulinic acid-3,5-3H to immature male rats leads to the incorporation of radioactivity into hemoprotein in the CO-binding particles. The incorporated radioactivity decreases in two distinct phases: a rapid phase with a half-life of 7-8 hr and a slow phase with a half-life of 46-48 hr. Treatment with phenobarbital or chlordane does not appreciably after the ratio of the fast-phase component to the slow-phase component but does increase the half-life to the fast phase of 11-12 hr. The increase in the protoheme content of the CO-binding particles found after phenobarbital and chlordane treatment suggests that these compounds increase the amount of both the rapidly and slowly decaying components.}, issn = {0026-895X}, URL = {https://molpharm.aspetjournals.org/content/5/5/499}, eprint = {https://molpharm.aspetjournals.org/content/5/5/499.full.pdf}, journal = {Molecular Pharmacology} }