PT  - JOURNAL ARTICLE
AU  - JAY C. UNKELESS
AU  - PETER GOLDMAN
TI  - Fluorinated γ-Aminobutyric Acid
DP  - 1970 Jan 01
TA  - Molecular Pharmacology
PG  - 46--53
VI  - 6
IP  - 1
4099  - http://molpharm.aspetjournals.org/content/6/1/46.short
4100  - http://molpharm.aspetjournals.org/content/6/1/46.full
SO  - Mol Pharmacol1970 Jan 01; 6
AB  - Glutamate decarboxylase (EC 4.1.1.15) of Escherichia coli reacts with L-γ-fluoroglutamate to form α-fluoro-γ-aminobutyric acid. This reaction has been characterized, and the two fluorinated amino acids have been investigated as selective inhibitors of γ-aminobutyric acid metabolism in the nervous system. L-γ-Fluoroglutamate inhibits the glutamate decarboxylase from calf brain (Ki = 1.4 x 10-2 M) at concentrations comparable to the Km of this enzyme for glutamate (10-2 M). In addition, α-fluoro-γ-aminobutyric acid inhibits the uptake of γ-aminobutyric acid in a nerve-muscle preparatiom from lobster.