RT Journal Article
SR Electronic
T1 Stargazin Differentially Controls the Trafficking of α-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and Kainate Receptors
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 703
OP 706
DO 10.1124/mol.64.3.703
VO 64
IS 3
A1 Lu Chen
A1 Alaa El-Husseini
A1 Susumu Tomita
A1 David S. Bredt
A1 Roger A. Nicoll
YR 2003
UL http://molpharm.aspetjournals.org/content/64/3/703.abstract
AB Synaptic plasticity at excitatory synapses in the brain is largely achieved by rapid changes in the number of synaptic α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (AMPA) receptors. Stargazin, a membrane protein that interacts with AMPA receptors, is believed to play a pivotal role in trafficking AMPA receptors to the plasma membrane and targeting them to the synapse. However, it is unclear whether the trafficking of kainate receptors, which are structurally very similar to AMPA receptors, is also dependent on stargazin. Here we show that in both cerebellar granule cells and in Xenopus laevis oocytes expression system, surface delivery of kainate receptor is independent of stargazin. These results suggest that stargazin action is highly selective for AMPA receptors.