TY - JOUR T1 - G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology JF - Molecular Pharmacology JO - Mol Pharmacol SP - 1 LP - 7 DO - 10.1124/mol.104.000497 VL - 66 IS - 1 AU - Graeme Milligan Y1 - 2004/07/01 UR - http://molpharm.aspetjournals.org/content/66/1/1.abstract N2 - It is now generally accepted that G protein-coupled receptors (GPCRs) can exist as dimers or as part of larger oligomeric complexes. Increasing evidence suggests that a dimer is the minimal functional structure, but considerable variation exists between reports of the effects of agonist ligands on quaternary structure. Many studies have intimated the existence of heterodimeric GPCR pairings. Key questions that remain to be addressed effectively include the prevalence and relevance of these in native tissues and the implications of heterodimerization for pharmacology and, potentially, for drug design. ER -