PT  - JOURNAL ARTICLE
AU  - Ana M. Rossi
AU  - Colin W. Taylor
TI  - Ca<sup>2+</sup> Regulation of Inositol 1,4,5-trisphosphate Receptors: Can Ca<sup>2+</sup> Function without Calmodulin?
AID  - 10.1124/mol.104.002592
DP  - 2004 Aug 01
TA  - Molecular Pharmacology
PG  - 199--203
VI  - 66
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/66/2/199.short
4100  - http://molpharm.aspetjournals.org/content/66/2/199.full
SO  - Mol Pharmacol2004 Aug 01; 66
AB  - All Ca2+ channels are regulated by Ca2+, a feature that allows them to respond to their own activity and to the activities of neighboring Ca2+ channels. Inhibition by Ca2+ protects cells from potentially hazardous increases in cytosolic [Ca2+], and stimulation can mediate facilitation and regenerative propagation of Ca2+ signals. Calmodulin is emerging as a key player in regulation of Ca2+ channels by Ca2+, but its role is more complex and more beautiful than might have been imagined.