RT Journal Article
SR Electronic
T1 Ca<sup>2+</sup> Regulation of Inositol 1,4,5-trisphosphate Receptors: Can Ca<sup>2+</sup> Function without Calmodulin?
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 199
OP 203
DO 10.1124/mol.104.002592
VO 66
IS 2
A1 Rossi, Ana M.
A1 Taylor, Colin W.
YR 2004
UL http://molpharm.aspetjournals.org/content/66/2/199.abstract
AB All Ca2+ channels are regulated by Ca2+, a feature that allows them to respond to their own activity and to the activities of neighboring Ca2+ channels. Inhibition by Ca2+ protects cells from potentially hazardous increases in cytosolic [Ca2+], and stimulation can mediate facilitation and regenerative propagation of Ca2+ signals. Calmodulin is emerging as a key player in regulation of Ca2+ channels by Ca2+, but its role is more complex and more beautiful than might have been imagined.