RT Journal Article SR Electronic T1 The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA? JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP 479 OP 487 DO 10.1124/mol.65.3.479 VO 65 IS 3 A1 Satish A. Eraly A1 Kevin T. Bush A1 Rosemary V. Sampogna A1 Vibha Bhatnagar A1 Sanjay K. Nigam YR 2004 UL http://molpharm.aspetjournals.org/content/65/3/479.abstract AB Renal organic anion secretion has been implicated in numerous clinically significant drug interactions and adverse reactions, indicating the importance of a detailed understanding of this pathway for the development of optimum therapeutics. With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic anion secretion has entered the molecular age. In this review, we focus on various aspects of the molecular biology and pharmacology of the OATs, including discussion of their structural biology, genomic organization in pairs, developmental regulation, toxicology, and pharmacogenetics. We propose functional, pathophysiological, and evolutionary hypotheses to help explain recent experimental and genomic data.