RT Journal Article
SR Electronic
T1 The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 479
OP 487
DO 10.1124/mol.65.3.479
VO 65
IS 3
A1 Satish A. Eraly
A1 Kevin T. Bush
A1 Rosemary V. Sampogna
A1 Vibha Bhatnagar
A1 Sanjay K. Nigam
YR 2004
UL http://molpharm.aspetjournals.org/content/65/3/479.abstract
AB Renal organic anion secretion has been implicated in numerous clinically significant drug interactions and adverse reactions, indicating the importance of a detailed understanding of this pathway for the development of optimum therapeutics. With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic anion secretion has entered the molecular age. In this review, we focus on various aspects of the molecular biology and pharmacology of the OATs, including discussion of their structural biology, genomic organization in pairs, developmental regulation, toxicology, and pharmacogenetics. We propose functional, pathophysiological, and evolutionary hypotheses to help explain recent experimental and genomic data.