TY - JOUR T1 - Pharmacology Meets Vesicular Trafficking at a Central Nervous System Synapse: Pregabalin Effects on Synaptic Vesicle Cycling in Hippocampal Neurons JF - Molecular Pharmacology JO - Mol Pharmacol SP - 444 LP - 446 DO - 10.1124/mol.106.026914 VL - 70 IS - 2 AU - Ronald W. Holz Y1 - 2006/08/01 UR - http://molpharm.aspetjournals.org/content/70/2/444.abstract N2 - The contribution by Micheva et al. (p. 467) in this issue of Molecular Pharmacology adds to our understanding of the action of pregabalin, a drug used for treatment of partial seizures and neuropathic pain. The authors examine the effects of pregabalin on presynaptic function of cultured hippocampal neurons using a powerful technique to follow the trafficking of synaptic vesicles in individual boutons. The study revealed that pregabalin reduces the readily releasable pool of synaptic vesicles in an N-methyl-d-aspartate receptor-dependent manner. ER -