PT  - JOURNAL ARTICLE
AU  - Gregg L. Semenza
TI  - Baffled by Bafilomycin: An Anticancer Agent That Induces Hypoxia-Inducible Factor-1α Expression
AID  - 10.1124/mol.106.031062
DP  - 2006 Dec 01
TA  - Molecular Pharmacology
PG  - 1841--1843
VI  - 70
IP  - 6
4099  - http://molpharm.aspetjournals.org/content/70/6/1841.short
4100  - http://molpharm.aspetjournals.org/content/70/6/1841.full
SO  - Mol Pharmacol2006 Dec 01; 70
AB  - In an article presented in this issue of Molecular Pharmacology, Lim et al. (p. 1856) investigate the anticancer effect of bafilomycin, an inhibitor of the vacuolar ATPase. The authors report that bafilomycin inhibits cell cycle progression and tumor growth by inducing the expression of hypoxia-inducible factor (HIF) 1α and the cyclin-dependent kinase inhibitor p21CIP1, a surprising result because HIF-1α overexpression is associated with tumor growth and angiogenesis in preclinical models and with increased patient mortality in clinical studies. However, the authors demonstrate that bafilomycin-induced HIF-1α expression leads to increased CIP1 gene expression but does not lead to increased expression of other HIF-1-regulated genes that promote tumor progression. The American Society for Pharmacology and Experimental Therapeutics