PT  - JOURNAL ARTICLE
AU  - Paul F. Pilch
AU  - Nils Bergenhem
TI  - Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes
AID  - 10.1124/mol.106.026104
DP  - 2006 Sep 01
TA  - Molecular Pharmacology
PG  - 779--785
VI  - 70
IP  - 3
4099  - http://molpharm.aspetjournals.org/content/70/3/779.short
4100  - http://molpharm.aspetjournals.org/content/70/3/779.full
SO  - Mol Pharmacol2006 Sep 01; 70
AB  - Obesity is now recognized as a rapidly increasing worldwide threat to health, largely as a result of causing diabetes. Thus, considerable efforts are underway in the pharmaceutical industry to find drugs to treat this condition. Target validation in various academic and industrial laboratories has revealed a number of potential molecular targets in fat cells or adipocytes. By definition, obesity is too much fat, and we here review efforts to treat obesity and, by proxy, diabetes by modulating the metabolic state of adipocytes. The American Society for Pharmacology and Experimental Therapeutics