RT Journal Article
SR Electronic
T1 Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 779
OP 785
DO 10.1124/mol.106.026104
VO 70
IS 3
A1 Paul F. Pilch
A1 Nils Bergenhem
YR 2006
UL http://molpharm.aspetjournals.org/content/70/3/779.abstract
AB Obesity is now recognized as a rapidly increasing worldwide threat to health, largely as a result of causing diabetes. Thus, considerable efforts are underway in the pharmaceutical industry to find drugs to treat this condition. Target validation in various academic and industrial laboratories has revealed a number of potential molecular targets in fat cells or adipocytes. By definition, obesity is too much fat, and we here review efforts to treat obesity and, by proxy, diabetes by modulating the metabolic state of adipocytes. The American Society for Pharmacology and Experimental Therapeutics