TY - JOUR T1 - Decursin Suppresses Human Androgen-Independent PC3 Prostate Cancer Cell Proliferation by Promoting the Degradation of β-Catenin JF - Molecular Pharmacology JO - Mol Pharmacol SP - 1599 LP - 1606 DO - 10.1124/mol.107.040253 VL - 72 IS - 6 AU - Gyu-Yong Song AU - Jee-Hyun Lee AU - Munju Cho AU - Byeoung-Soo Park AU - Dong-Eun Kim AU - Sangtaek Oh Y1 - 2007/12/01 UR - http://molpharm.aspetjournals.org/content/72/6/1599.abstract N2 - Alterations in the Wnt/β-catenin pathway are associated with the development and progression of human prostate cancer. Decursin, a pyranocoumarin isolated from the Korean Angelica gigas root, inhibits the growth of androgen-independent human prostate cancer cells, but little is known about its mechanism of action. Using a cell-based screen, we found that decursin attenuates the Wnt/β-catenin pathway. Decursin antagonized β-catenin response transcription (CRT), which was induced with Wnt3a-conditioned medium and LiCl, by promoting the degradation of β-catenin. Furthermore, decursin suppressed the expression of cyclin D1 and c-myc, which are downstream target genes of β-catenin and thus inhibited the growth of PC3 prostate cancer cells. In contrast, decursinol, in which the (CH3)2–C=CH–COO–side chain of decursin is replaced with–OH, had no effect on CRT, the level of intracellular β-catenin, or PC3 cell proliferation. Our findings suggest that decursin exerts its anticancer activity in prostate cancer cells via inhibition of the Wnt/β-catenin pathway. The American Society for Pharmacology and Experimental Therapeutics ER -