TY - JOUR T1 - Theoretical Considerations of <em>Alpha</em> and <em>Beta</em> Adrenergic Activity JF - Molecular Pharmacology JO - Mol Pharmacol SP - 328 LP - 336 VL - 7 IS - 3 AU - JACK M. GEORGE AU - LEMONT B. KIER AU - JAMES R. HOYLAND Y1 - 1971/05/01 UR - http://molpharm.aspetjournals.org/content/7/3/328.abstract N2 - It appears that N-alkyl groups necessary for beta adrenergic activity act directly on the receptor rather than by influencing the conformation of the side chain relative to the catechol ring or the charge distribution around the nitrogen. While alpha activity probably involves hydrogen bond formation between an onium proton and a negatively charged receptor, beta activity is likely to involve dispersion binding between the alkyl group and receptor such that the nitrogen may not be necessary for beta activity. ACKNOWLEDGMENTS We wish to acknowledge the assistance and use of the computer facilities of the Battelle Memorial Institute and the Ohio State University. ER -