RT Journal Article
SR Electronic
T1 Theoretical Considerations of <em>Alpha</em> and <em>Beta</em> Adrenergic Activity
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 328
OP 336
VO 7
IS 3
A1 JACK M. GEORGE
A1 LEMONT B. KIER
A1 JAMES R. HOYLAND
YR 1971
UL http://molpharm.aspetjournals.org/content/7/3/328.abstract
AB It appears that N-alkyl groups necessary for beta adrenergic activity act directly on the receptor rather than by influencing the conformation of the side chain relative to the catechol ring or the charge distribution around the nitrogen. While alpha activity probably involves hydrogen bond formation between an onium proton and a negatively charged receptor, beta activity is likely to involve dispersion binding between the alkyl group and receptor such that the nitrogen may not be necessary for beta activity. ACKNOWLEDGMENTS We wish to acknowledge the assistance and use of the computer facilities of the Battelle Memorial Institute and the Ohio State University.