TY - JOUR T1 - Crystallizing Thinking about the β2-Adrenergic Receptor JF - Molecular Pharmacology JO - Mol Pharmacol SP - 1333 LP - 1338 DO - 10.1124/mol.108.045849 VL - 73 IS - 5 AU - Arun K. Shukla AU - Jin-Peng Sun AU - Robert J. Lefkowitz Y1 - 2008/05/01 UR - http://molpharm.aspetjournals.org/content/73/5/1333.abstract N2 - Two recently determined crystal structures of the human β2-adrenergic receptor (β2AR) provide a long-awaited advance in the field of G protein-coupled receptor research. The β2AR is only the second member of this, the largest family of receptors encoded in the human genome, whose structure has been solved. It follows structures of rhodopsin that were determined previously. Here we set these developments in historical context, discuss the daunting challenges that have been overcome, and appraise what has and has not been learned. ER -