RT Journal Article
SR Electronic
T1 Crystallizing Thinking about the β2-Adrenergic Receptor
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 1333
OP 1338
DO 10.1124/mol.108.045849
VO 73
IS 5
A1 Arun K. Shukla
A1 Jin-Peng Sun
A1 Robert J. Lefkowitz
YR 2008
UL http://molpharm.aspetjournals.org/content/73/5/1333.abstract
AB Two recently determined crystal structures of the human β2-adrenergic receptor (β2AR) provide a long-awaited advance in the field of G protein-coupled receptor research. The β2AR is only the second member of this, the largest family of receptors encoded in the human genome, whose structure has been solved. It follows structures of rhodopsin that were determined previously. Here we set these developments in historical context, discuss the daunting challenges that have been overcome, and appraise what has and has not been learned.