RT Journal Article SR Electronic T1 The Stereochemical Basis of Anticonvulsant Drug Action JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP 406 OP 412 VO 7 IS 4 A1 NORMAN CAMERMAN A1 ARTHUR CAMERMAN YR 1971 UL http://molpharm.aspetjournals.org/content/7/4/406.abstract AB The crystal and molecular structure of procyclidine (α-cyclohexyhl-α-phenyl-1-pyrrolidinepropanol) has been determined in order to investigate structural bases for its biological activity as an aniticonvulsant drug. Crystals of procyclidine hydrochloride are monoclinic, space group P21/c, with cell dimensions a = 5.891 ± 0.006, b = 28.603 ± 0.018, c = 11.314 ± 0.004 A, β = 106.0 degrees ± 15', Z = 4 molecules/cell. The structure was determined by the symbolic addition procedure, utilizing data collected on an automated diffractometer (CuKα radiation). Refinement was accomplished by an anisotropic full-matrix least-squares procedure, resulting in a final R value of 0.081. Stereochemical features which the molecule has in common with other anticonvulsants, diphenylhydantoin and diazepam, and which may account for its anticonvulsant activity are analyzed and discussed. ACKNOWLEDGMENTS The authors thank Dr. H. Kalant for supplying the procyclidine hydrochloride.