PT  - JOURNAL ARTICLE
AU  - DEVYNCK, M. A.
AU  - BOQUET, P. L.
AU  - FROMAGEOT, P.
AU  - SIMON, E. J.
TI  - On the Mode of Action of Levallorphan on <em>Escherichia coli:</em> Effects on Cellular Magnesium
DP  - 1971 Nov 01
TA  - Molecular Pharmacology
PG  - 605--610
VI  - 7
IP  - 6
4099  - http://molpharm.aspetjournals.org/content/7/6/605.short
4100  - http://molpharm.aspetjournals.org/content/7/6/605.full
SO  - Mol Pharmacol1971 Nov 01; 7
AB  - Inhibition of the growth of Escherichia coli by levallorphan increased in effectiveness as the medium concentration of Mg++ was decreased. Two molecules of levallorphan were shown to compete with 1 atom of Mg++, presumably on the cell surface. Active transport of Mg++ was altered in the presence of the drug, and this effect could be prevented by high concentrations of Ca++. Reduction of cellular Mg++ content in the presence of levallorphan is suggested to be one possible cause of growth inhibition.