RT Journal Article
SR Electronic
T1 On the Mode of Action of Levallorphan on <em>Escherichia coli:</em> Effects on Cellular Magnesium
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 605
OP 610
VO 7
IS 6
A1 M. A. DEVYNCK
A1 P. L. BOQUET
A1 P. FROMAGEOT
A1 E. J. SIMON
YR 1971
UL http://molpharm.aspetjournals.org/content/7/6/605.abstract
AB Inhibition of the growth of Escherichia coli by levallorphan increased in effectiveness as the medium concentration of Mg++ was decreased. Two molecules of levallorphan were shown to compete with 1 atom of Mg++, presumably on the cell surface. Active transport of Mg++ was altered in the presence of the drug, and this effect could be prevented by high concentrations of Ca++. Reduction of cellular Mg++ content in the presence of levallorphan is suggested to be one possible cause of growth inhibition.