RT Journal Article
SR Electronic
T1 Release of Free Bases from Deoxyribonucleic Acid after Reaction with Bleomycin
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 531
OP 537
VO 8
IS 5
A1 CHARLES W. HAIDLE
A1 K. KAY WEISS
A1 M. TIEN KUO
YR 1972
UL http://molpharm.aspetjournals.org/content/8/5/531.abstract
AB Labeled free bases could be detected chromatographically after reaction of deoxyribonucleic acid with high concentrations of the antibiotic bleomycin. Thymine, adenine, guanine, and cytosine were released from DNAs previously labeled in the base moiety with each of the four bases. No detectable amounts of nucleosides, nucleotides, deoxyribose, deoxyribose phosphate, or inorganic phosphate were released. ACKNOWLEDGMENTS The authors with to thank Mrs. Elsie Jackson for her excellent technical assistance, and to express appreciation to Dr. L. Daniel Inners for his assistance in the molecular weight determination.