TY - JOUR T1 - Comparative Study of Estrogen Action JF - Molecular Pharmacology JO - Mol Pharmacol SP - 520 LP - 533 VL - 9 IS - 4 AU - JEAN-PIERRE RAYNAUD AU - MARIE-MADELEINE BOUTON AU - DANIELLE GALLET-BOURQUIN AU - DANIEL PHILIBERT AU - COLETTE TOURNEMINE AU - GENEVIÈVE AZADIAN-BOULANGER Y1 - 1973/07/01 UR - http://molpharm.aspetjournals.org/content/9/4/520.abstract N2 - By comparing 16 estradiol derivatives, it has been possible to assess the relative influence of distribution, metabolism, uterine uptake, and plasma and tissue binding on uterotrophic activity in the rat. This comparison has revealed that all active compounds are bound in vivo to the 8 S uterus cytosol receptor, but that their activity cannot be related to binding in vitro, owing to the many factors acting on the compound in vivo prior to the triggering of the biological response. It is suggested that only the free molecule in the plasma is active on the uterus and that consequently activity is modulated by plasma binding. ER -