PT  - JOURNAL ARTICLE
AU  - NEVILLE BROOKES
AU  - MARTIN BLANK
AU  - ROBERT WERMAN
TI  - The Kinetics of the Conductance Increase Produced by γ-Aminobutyric Acid at the Membrane of Locust Muscle Fibers
DP  - 1973 Jul 01
TA  - Molecular Pharmacology
PG  - 580--589
VI  - 9
IP  - 4
4099  - http://molpharm.aspetjournals.org/content/9/4/580.short
4100  - http://molpharm.aspetjournals.org/content/9/4/580.full
SO  - Mol Pharmacol1973 Jul 01; 9
AB  - The membrane response to γ-aminobutyric acid (GABA) of locust muscle fibers bathed in "propionate saline" at pH 6.5 is generally biphasic. The slow phase is exponential, and its rate constant (5.5 x 10-3 to 1.0 x 10-2 sec-1) is independent of GABA concentration and relatively insensitive to temperature change (from 26° to 15°). With increasing GABA concentration and temperature, a faster process intervenes. A form of "sensitization" occurs in which the participation of the fast component of the kinetics increases on repeated application of the same GABA concentration. Equilibrium curves of GABA action were obtained at different temperatures, and a van't Hoff plot was constructed. The standard enthalpy change, ΔH°, for the over-all interaction between GABA and receptor is -59.3 kcal/mole.