PT  - JOURNAL ARTICLE
AU  - C. A. BUSH
AU  - A. PESCE
AU  - M. GAIZUTIS
AU  - V. NAIR
TI  - Binding and Circular Dichroism Studies on Interactions of Lysergic Acid Diethylamide with Deoxyribonucleic Acid
DP  - 1972 Jan 01
TA  - Molecular Pharmacology
PG  - 104--109
VI  - 8
IP  - 1
4099  - http://molpharm.aspetjournals.org/content/8/1/104.short
4100  - http://molpharm.aspetjournals.org/content/8/1/104.full
SO  - Mol Pharmacol1972 Jan 01; 8
AB  - The interactions of d- and l-lysergic acid diethylamide (LSD) with DNA were studied by means of equilibrium dialysis and circular dichroism. There was no significant difference between the binidinig of d- and l-LSD to DNA. Circular dichroism data do not favor intercalation, and it is suggested that LSD is probably bound outside the DNA helix, perhaps to the phosphate groups of DNA by some ionic mechanism. ACKNOWLEDGMENT We thank Professor Irving Klotz, Northwestern University, for helpful comments and Messrs. D. Bau and S. Siegel for technical assistance.