RT Journal Article
SR Electronic
T1 Genetic Expression of the Induction of Epoxide Hydrase and Aryl Hydrocarbon Hydroxylase Activities in the Mouse by Phenobarbital or 3-Methylcholanthrene
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 692
OP 696
VO 9
IS 5
A1 FRANZ OESCH
A1 NOREEN MORRIS
A1 JOHN W. DALY
A1 JACQUES E. GIELEN
A1 DANIEL W. NEBERT
YR 1973
UL http://molpharm.aspetjournals.org/content/9/5/692.abstract
AB Intraperitoneal administration of phenobarbital causes significant induction of hepatic epoxide hydrase activity in C57BL/6N, C3H/HeN, NZB/BLN, and NZW/BLN inbred strains of mice and not in DBA/2N, N:GP(SW), and AL/N strains, whereas a hepatic monooxygenase [aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity is stimulated 1.5-3-fold in all seven strains. Intraperitoneal administration of 3-methylcholanthrene has virtually no effect on the hydrase activity in any of the seven strains. The aromatic hydrocarbon increases the hydroxylase activity 2-6-fold in C57BL/6N, N:GP(SW), AL/N, and C3H/HeN mice but causes no significant rise in the hepatic enzyme activity in DBA/2N, NZB/BLN, and NZW/BLN mice. In appropriate crosses between C57BL/6N and DBA/2N, the expression of epoxide hydrase induction by phenobarbital appears so complex as to preclude any simple genetic analysis; the basal hydrase levels appear to be inherited additively.