RT Journal Article
SR Electronic
T1 Evidence for a Ternary Complex Containing Albumin, Copper, and Penicillamine
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 249
OP 255
VO 8
IS 2
A1 YUKIO SUGIURA
A1 HISASHI TANAKA
YR 1972
UL http://molpharm.aspetjournals.org/content/8/2/249.abstract
AB The interaction between penicillamine and albumin-bound copper has been investigated. The presence of a ternary complex involving albumin, copper and penicillamine as an intermediate step in the course of the removal of copper has been demonstrated by gel filtration technique with [3H]penicillamine and 64Cu. Copper is presumed to exist in the complex in both the cupric and cuprous states. These findings suggest a mechanism for the migration of copper from the albumin—copper(II) complex to penicillamine, and explain the unique reductive chelating action of penicillamine in the treatment of Wilson's disease.