PT  - JOURNAL ARTICLE
AU  - Neil J. McKenna
TI  - Research Resources for Nuclear Receptor Signaling Pathways
AID  - 10.1124/mol.116.103713
DP  - 2016 Aug 01
TA  - Molecular Pharmacology
PG  - 153--159
VI  - 90
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/90/2/153.short
4100  - http://molpharm.aspetjournals.org/content/90/2/153.full
SO  - Mol Pharmacol2016 Aug 01; 90
AB  - Nuclear receptor (NR) signaling pathways impact cellular function in a broad variety of tissues in both normal physiology and disease states. The complex tissue-specific biology of these pathways is an enduring impediment to the development of clinical NR small-molecule modulators that combine therapeutically desirable effects in specific target tissues with suppression of off-target effects in other tissues. Supporting the important primary research in this area is a variety of web-based resources that assist researchers in gaining an appreciation of the molecular determinants of the pharmacology of a NR pathway in a given tissue. In this study, selected representative examples of these tools are reviewed, along with discussions on how current and future generations of tools might optimally adapt to the future of NR signaling research.