RT Journal Article
SR Electronic
T1 Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 627
OP 632
DO 10.1124/mol.116.104927
VO 90
IS 5
A1 Paula G. Slater
A1 Hector E. Yarur
A1 Katia Gysling
YR 2016
UL http://molpharm.aspetjournals.org/content/90/5/627.abstract
AB The corticotropin-releasing factor (CRF) system, which is involved in stress, addiction, and anxiety disorders such as depression, acts through G-protein–coupled receptors (GPCRs) known as type-1 and type-2 CRF receptors. The purpose of this review is to highlight recent advances in the interactions of CRF receptors with other GPCRs and non-GPCR proteins and their associated functional consequences. A better understanding of these interactions may generate new pharmacological alternatives for the treatment of addiction and stress-related disorders.