RT Journal Article SR Electronic T1 Notch Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP 676 OP 693 DO 10.1124/mol.117.110254 VO 92 IS 6 A1 Musaddique Hussain A1 Chengyun Xu A1 Mashaal Ahmad A1 Youping Yang A1 Meiping Lu A1 Xiling Wu A1 Lanfang Tang A1 Ximei Wu YR 2017 UL http://molpharm.aspetjournals.org/content/92/6/676.abstract AB Lung development is mediated by assorted signaling proteins and orchestrated by complex mesenchymal-epithelial interactions. Notch signaling is an evolutionarily conserved cell-cell communication mechanism that exhibits a pivotal role in lung development. Notably, both aberrant expression and loss of regulation of Notch signaling are critically linked to the pathogenesis of various lung diseases, in particular, pulmonary fibrosis, lung cancer, pulmonary arterial hypertension, and asthmatic airway remodeling; implying that precise regulation of intensity and duration of Notch signaling is imperative for appropriate lung development. Moreover, evidence suggests that Notch signaling links embryonic lung development and asthmatic airway remodeling. Herein, we summarized all-recent advances associated with the mechanistic role of Notch signaling in lung development, consequences of aberrant expression or deletion of Notch signaling in linking early-impaired lung development and asthmatic airway remodeling, and all recently investigated potential therapeutic strategies to treat asthmatic airway remodeling.