PT - JOURNAL ARTICLE AU - Joyce Koenen AU - Françoise Bachelerie AU - Karl Balabanian AU - Géraldine Schlecht-Louf AU - Carmen Gallego TI - Atypical Chemokine Receptor 3 (ACKR3): A Comprehensive Overview of its Expression and Potential Roles in the Immune System AID - 10.1124/mol.118.115329 DP - 2019 Dec 01 TA - Molecular Pharmacology PG - 809--818 VI - 96 IP - 6 4099 - http://molpharm.aspetjournals.org/content/96/6/809.short 4100 - http://molpharm.aspetjournals.org/content/96/6/809.full SO - Mol Pharmacol2019 Dec 01; 96 AB - Atypical chemokine receptor 3 (ACKR3), previously known as C-X-C chemokine receptor type 7 (CXCR7), has emerged as a key player in several biologic processes, particularly during development. Its CXCL11 and CXCL12 scavenging activity and atypical signaling properties, together with a new array of other nonchemokine ligands, have established ACKR3 as a main regulator of physiologic processes at steady state and during inflammation. Here, we present a comprehensive review of ACKR3 expression in mammalian tissues in search of a possible connection with the receptor function. Besides the reported roles of ACKR3 during development, we discuss the potential contribution of ACKR3 to the function of the immune system, focusing on the myeloid lineage.