PT  - JOURNAL ARTICLE
AU  - Chase H Melick
AU  - Tshering D Lama-Sherpa
AU  - Adna Curukovic
AU  - Jenna L Jewell
TI  - GPCR Signaling and mTORC1 Regulation
AID  - 10.1124/molpharm.121.000302
DP  - 2021 Jan 01
TA  - Molecular Pharmacology
PG  - MOLPHARM-MR-2021-000302
4099  - http://molpharm.aspetjournals.org/content/early/2021/12/28/molpharm.121.000302.short
4100  - http://molpharm.aspetjournals.org/content/early/2021/12/28/molpharm.121.000302.full
AB  - The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions such as metabolism, growth, and autophagy. The activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues to be an important therapeutic target. Understanding the upstream regulators of mTORC1 will provide a crucial link to targeting mTORC1 hyperactivated diseases. In this review, we will discuss the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor (GPCR) signaling to mTORC1. Significance Statement mTORC1 is a master regulator of many cellular processes and is often hyperactivated in human disease. Therefore, understanding the molecular underpinnings of these pathways will undoubtedly be promising to the mTORC1 field and human disease.