EC50 | |||
---|---|---|---|
Compound | MT-4 | MT-4/DOX500 | Fold resistance |
μM | |||
AZT | 0.013 ± 0.003 | 0.094 ± 0.062 | 7.5 |
3TC | 1.3 ± 0.7 | >100 | >77 |
ddI | 12.3 ± 2.7 | 32.5 ± 5.0 | 2.7 |
d4T | 0.33 ± 0.05 | 0.53 ± 0.08 | 1.6 |
NVP | 0.10 ± 0.02 | 0.11 ± 0.02 | 1.1 |
EMV | 0.015 ± 0.006 | 0.018 ± 0.008 | 1.2 |
IDV | 0.041 ± 0.028 | 0.018 ± 0.009 | 0.5 |
NFV | 0.023 ± 0.003 | 0.018 ± 0.008 | 0.8 |
All data represent means ± S.D. for three separate experiments.
Fold resistance, ratio of EC50 in MT-4 cells to EC50 in MT-4/DOX500 cells; ddI, didanosine; d4T, stavudine; NVP, nevirapine; EMV, emivirine; IDV, indinavir.