Table 2

Other GPCR helix-helix interactions found experimentally.

Residue IndicesReceptorsExperimental MethodsResidues/MutationsCβ-CβReferences
CRZ
1.39 7.36ACM2-ACM5 + T37A H423T11.8 Liu et al., 1995
2.50 7.49GRHR + N87D D318N7.0 Zhou et al., 1994
2.50 7.495H2A + D120N N376D7.0 Sealfon et al., 1995
2.64 3.28NK1R + Y92H H1086.6 Elling and Schwartz, 1996
3.29 5.35NK1R + N109H E193H14.0 Elling and Schwartz, 1996
3.32 7.39B2AR + D113H N312C15.52-a Elling et al., 1999
3.43 6.44ACM1 + L116H F374H6.3 Lu and Hulme, 2000
3.43 7.49ACM1 + L116H N414H10.1 Lu and Hulme, 2000
3.53 6.30B2AR + A134H E268H6.1 Sheikh et al., 1999
3.53 6.31B2AR + A134H H26910.7 Sheikh et al., 1999
3.53 6.34B2AR + A134H L272H8.3 Sheikh et al., 1999
3.54 6.29ACM2 + I169C K484C11.5 Zeng et al., 1999
3.54 6.30ACM3 + I169C E485C6.3 Zeng et al., 1999
3.54 6.31ACM3 + I169C K486C8.2 Zeng et al., 1999
3.54 6.32ACM3 + I169C K487C11.8 Zeng et al., 1999
3.54 6.33ACM3 + I169C A488C8.9 Zeng et al., 1999
3.54 6.34ACM3 + I169C A489C5.7 Zeng et al., 1999
3.54 6.35ACM3 + I169C Q490C10.8 Zeng et al., 1999
3.54 6.36ACM3 + I169C T491C12.4 Zeng et al., 1999
5.35 6.59NK1R + E193H Y272H9.0 Elling et al., 1995
5.39 6.55NK1R + H197 F268H8.6 Elling et al., 1995
5.39 6.56NK1R + H197 L269H8.5 Elling et al., 1995
5.39 6.59NK1R + H197 Y272H5.1 Elling et al., 1995
6.44 7.49ACM1 + F374H N414H9.0 Lu and Hulme, 2000
TM1/TM2 7.39B2AR-A2AA + N312F Mizobe et al., 1996
TM3/TM6 7.38B2AR-A2AA + L311F Mizobe et al., 1996

Cβ-Cβ is the distance between the Cβ of two residues in bovine rhodopsin structure. Receptor names are abbreviated according to their SWISS-PROT Annotated Protein Sequence Database entry names:http://www.expasy.ch/cgi-bin/lists?7tmrlist.txt

• C, Cys-Cys crosslinking; R, double revertant mutations; Z, Zinc-His binding; E, spin-labeling; L, ligand related; F, Fourier-transform infrared difference spectroscopy.

• 2-a  Present only in the active state.