Acute Drug | Chronic Pre-treatment | BindingK_{i} | Adenylyl Cyclase | |
---|---|---|---|---|
IC_{50} | I_{MAX} | |||
nM | nM | % | ||
Morphine | None | 7.20 ± 1.60^{1-a} ^{1-b} | 81.0 ± 1.30^{1-c} | 57.0 ± 2.30^{1-c} |
DAMGO | None | 1.00 ± 0.60^{1-a} | 18.6 ± 4.50^{1-e} ^{1-f} | 76.2 ± 1.66^{1-e} ^{1-f} |
DAMGO | Morphine | N.T. | 34.9 ± 22.1^{1-f} | 34.0 ± 2.57^{1-d} ^{1-f} |
DAMGO | DAMGO | N.T. | 325 ± 99.1^{1-d} ^{1-e} | 19.8 ± 3.50^{1-d} ^{1-e} |
↵1-a Values obtained from Piros et al., 1995.
↵1-b Significantly different from corresponding (Acute) DAMGO/(Chronic) None value, p < 0.05, (unpaired Student's t test).
↵1-c Significantly different from corresponding (Acute) DAMGO/(Chronic) None value, p < 0.01 (unpaired Student's t test).
↵1-d Significantly different from corresponding (Acute) DAMGO/(Chronic) None value, p < 0.05 (Tukey's test).
↵1-e Significantly different from corresponding (Acute) DAMGO/(Chronic) Morphine value, p< 0.05 (Tukey's test).
↵1-f Significantly different from corresponding (Acute) DAMGO/(Chronic) DAMGO value, p < 0.05 (Tukey's test).
N.T., not tested.