Table 1

Forskolin-stimulated cAMP accumulations in tissue from D1A-deficient mutant mice

StriatumCortex
Wild-type miceD1Aknockout miceWild-type miceD1Aknockout mice
Basal136  ± 131-a 139  ± 1259  ± 855  ± 8
Forskolin (10 μm)847  ± 161-b 796  ± 311-b 424  ± 361-b 460  ± 141-b
  • 1-a Values represent cAMP accumulations in pmol/min/mg of striatal or cortical membranes measured in the presence of 1 μm GTP. Each value is mean ± standard error of seven individual experiments.

  • 1-b p < 0.01 compared with the respective basal activity.