Table 1

Alignment of the amino-terminal sequence of UDP-glycosyltransferases

Enzyme	n
UGT1^*6	46	Val	Glu	Val	Leu	Ser	Asp	Arg	Gly	His	Glu	Ile	Val	Val	Val	Pro	Glu	Val
UGT1^*06	45	Val	Glu	His	Leu	Ser	Glu	Arg	Gly	His	Asp	Ile	Val	Leu	Val	Pro	Glu	Val
UGT1^*1	47	Ile	Gln	Gln	Leu	Gln	Gln	Arg	Gly	His	Glu	Ile	Val	Val	Leu	Ala	Pro	Asp
UGT1^*4	48	Leu	Arg	Glu	Leu	His	Ala	Arg	Gly	His	Gln	Ala	Val	Val	Leu	Trp	Pro	Glu
UGT1^*0	45	Val	Arg	Glu	Leu	His	Ala	Arg	Gly	His	Asp	Ala	Val	Leu	Ala	Pro	Glu	Val
UGT2B8	43	Leu	Glu	Glu	Leu	Val	Gln	Arg	Gly	His	Gln	Val	Val	Leu	Thr	Ser	Ser	Ala
UGT2B4	43	Leu	Asp	Glu	Leu	Val	Gln	Arg	Gly	His	Glu	Val	Val	Leu	Ala	Ser	Ser	Ala
UGT2B7	43	Leu	Asp	Glu	Leu	Ile	Gln	Arg	Gly	His	Glu	Val	Val	Leu	Ala	Ser	Ser	Ala
UGT2B3	43	Leu	Asp	Glu	Leu	Val	Gln	Arg	Gly	His	Glu	Val	Val	Leu	Lys	Pro	Ser	Ala
UGT2B1	43	Leu	Asp	Glu	Leu	Val	Gln	Arg	Gly	His	Glu	Val	Val	Leu	Lys	Pro	Ser	Ala
UGT2B6	43	Leu	Asn	Glu	Leu	Ala	Gln	Arg	Gly	His	Glu	Val	Val	Leu	Val	Ser	Ser	Ala
Ugt2b5	43	Leu	Asp	Glu	Leu	Val	Gln	Arg	Gly	His	Glu	Val	Val	Leu	Lys	Pro	Ser	Ala
UGT2B2	43	Leu	Asp	Glu	Leu	Val	Gln	Arg	Gly	His	Glu	Val	Val	Leu	Arg	Pro	Ser	Ala
C-Gal-T	42	Ala	Ser	Ala	Leu	His	Glu	Arg	Gly	His	His	Thr	Val	Phe	Leu	Leu	Ser	Gly
E-Gluc-T	40	Ile	Glu	Ala	Leu	Ala	Glu	Lys	Cys	His	Asn	Val	Thr	Val	Val	Lys	Pro	Lys

The cDNA-derived amino acid sequences of different UGT isoforms, of a ceramide-galactosyltransferase (C-Gal-T), and of an ecdysteroid glucosyltransferase (E-Gluc-T) obtained from the SwissProt data bank were aligned using the PileUp program from the GCG package (Genetics Computer Group, Madison, WI). The number (n) indicates the position of the first amino acid of the alignment. Mutated residues are indicated in bold.