Table 1

Effects of polyamine analogs at NMDA receptors

Subunit combinationPolyamineIC50nH No. of oocytes
μm
NR1/NR2ASpermidine1539  ± 2051.1  ± 0.15
NR1/NR2An1-DnsSpd3.8  ± 0.71.0  ± 0.16
NR1/NR2AN8-DnsSpd7.9  ± 1.20.8  ± 0.15
NR1/NR2ASpermine519  ± 891.0  ± 0.16
NR1/NR2AN1-OsSpm0.42  ± 0.040.8  ± 0.16
NR1/NR2AN1-DnsSpm0.31  ± 0.040.9  ± 0.16
NR1/NR2BN1-DnsSpm0.34  ± 0.100.8  ± 0.16
NR1/NR2CN1-DnsSpm16.1  ± 1.41.1  ± 0.15
NR1/NR2DN1-DnsSpm13.1  ± 0.81.1  ± 0.15

Values for the IC50 and Hill slope (nH ) of inhibition by spermidine, spermine, and their analogs were determined from concentration-inhibition curves using oocytes expressing NR1/NR2 receptors and voltage-clamped at −70 mV. Values are mean ± standard error.