Table 1

Pharmacokinetic parameters of ¹²⁵I-rR-RAGE after intravenous administration

	t_1/2λ1	t_1/2λ2	t_1/2λz	CL	V_z	V_ss	MRT	AUC
	hr	hr	hr	ml/hr/kg	liter/kg	liter/kg	hr	ng/hr/ml
Diabetic rat (n = 5)	0.15 ± 0.03	4.01 ± 0.87	57.17 ± 11.62	108.89 ± 50.09	6.94 ± 1.40	4.85 ± 1.24	34.11 ± 9.17	2856 ± 1120
Normal rat (n = 5)	0.02 ± 0.01	0.21 ± 0.07	26.02 ± 2.36	88.15 ± 22.92	3.24 ± 0.76	2.60 ± 0.61	32.41 ± 3.71	3152 ± 916
p	0.008	0.008	0.008	0.690	0.049	0.032	1.000	0.690

Values are mean ± standard error.

V_ss, steady state volume of distribution; MRT, mean residence time; AUC, area under the curve.