Table 2

Resistance of transfected HEK 293 cells to heavy metal oxyanions

CompoundIC50Resistance factor
HEKPC7HEKmrpHEKMRPHEKmrpHEKMRP
μg/ml
Potassium antimony tartrate11.78  ± 2.2237.67  ± 10.4333.70  ± 9.283.22.9
Sodium arsenite1.76  ± 0.414.72  ± 0.242.91  ± 1.052.71.7

The IC50 values of both compounds were determined as described in Table 1. Values are the mean ± standard deviation from three or four independent experiments. Statistical significance was determined using an unpaired Student t test. The resistance factor was calculated as described in Table 1. Values obtained with the resistant cells, HEKMRP and HEKmrp, are significantly different from those obtained with the sensitive cells, HEKPC7 (p≤ 0.05).