Cross resistance profile at 35° of JN394t2-4 transformed with wild-type and mutant TOP2 alleles
| Plasmid | Mutation in topo somerase II | MLC | ||
|---|---|---|---|---|
| Doxorubicin | Amsacrine | Etoposide | ||
| μg/ml | ||||
| YCpDEDWOB10 | 6 | 6 | 15 | |
| YCpDEDWOB10-R1F | G748E | 50 | >100 | >100 |
| YCpDEDWOB10-R2F | A642S | 50 | >100 | >100 |