Table 6

MCF-7 cells: displacement of [125I]amylin

AntagonistMean pKi AgonistMean pKi
AC5129.56  ± 0.15rAMYLIN9.7  ± 0.2
(n = 6) (n = 10)
AC669.68  ± 0.05Rat CAL7.56  ± 0.25
(n = 5)(n = 5)
AC4139.3  ± 0.24hCAL7.33  ± 0.25
(n = 4)(n = 8)
hCGRP8–37 6.51  ± 0.12rCGRP9.29  ± 0.1
(n = 4)(n = 9)